We strongly recommend suppressing the original sentence regarding section step three

We surmise that results obtained from the experiments described in this section cannot serve to understand the role of I_NaL in arrhythmogenesis.

step 1. Van Driessche W, Lindemann B: Amount reliance from currents because of solitary salt-selective pores for the frog skin. Characteristics. 1979; 282 (5738): 519-520 PubMed Conceptual | Copywriter Complete Text message

It means the newest solid findings put forward from this manuscript are not warranted and i you should never accept this new manuscript within mode

The brand new people have clarified many of the inquiries We elevated during the my personal previous comment. Unfortunately, the big issues haven’t been handled through this update. Whenever i manufactured in my earlier opinion, We consider they unrealistic that all those individuals activities can be repaired only because of the several added sentences. Alternatively you can still find particular important questions to the fresh framework and you may, very vitally, toward analysis.

It indicates the latest solid conclusions put forward by this manuscript is actually maybe not justified and i you should never approve the latest manuscript within this setting

New experts has clarified many of the concerns I raised during the my personal earlier comment. Unfortuitously, the biggest difficulties have not been handled through this update. When i produced in my earlier in the day feedback, I deem it impractical that most the individuals facts are fixed only by the several extra paragraphs. Instead you can still find certain important questions to your experimental framework and you will, really significantly, to your data.

• The number one issue is that when I used the newest breakdown off the ways in the last version it actually was you can to help you decode, which have almost primary reliability, one arbitrary stimuli labels I chose. See to have types of which reanalysis. Regardless of whether we imagine your real stimulus featured from the an after day otherwise was consistently switching ranging from rule and you can quiet, brand new decryption is near to best. It is an indication your decryption doesn’t have anything to-do into the genuine stimuli read from the Sender but is opportunistically exploiting more provides throughout the study. The latest handle data the newest authors did, treating the stimulus brands, cannot target this issue because is suffering from equivalent condition. Fundamentally, exactly what the classifier is actually allegedly playing with is the time who may have introduced because the tape already been.
• The reason for it is presumably your writers utilized non-separate data to own training and review. Of course I’m sure precisely (pick area step 3), haphazard testing one half of data examples regarding an enthusiastic EEG shade aren’t independent analysis. Continual the study five times – the latest control study brand new writers performed – is not an adequate answer to target so it question. Randomly in search of examples away from a time show that has sluggish alter (like the sluggish wave pastime you to presumably dominates this type of tracks under these scenarios) often inevitably incorporate solid temporal correlations. Come across TemporalCorrelations.jpg set for 2D occurrence histograms and you will a correlation matrix exhibiting which.
• As revised steps point will bring increased detail now, they still is confused about just what research were utilized. Old-fashioned classification data statement just what studies features (common articles about data matrix) and you can what observations (typical rows) were used. Some thing is a feature however, usually this is certainly brand new more EEG channels or fMRI voxels an such like. Observations are big date issues. Right here I guess this new writers switched the latest raw trials into good some other place playing with dominant parts data. It is not said in the event your dimensionality try quicker using the eigenvalues. Regardless, I suppose the details trials buy personal statement (built-up from the 128 Hz) was basically after that put given that observations additionally the EEG channels transformed because of the PCA were used since the possess. This new stimulus names was in fact assigned just like the With the otherwise Regarding for each take to. A collection of 50% from products (and you may brands) was then selected randomly to own training, and also the rest was applied having investigations. So is this best?